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Platelets, the fundamental element of primary hemostasis, are also known to be reservoirs for many growth factors (GFs), which they store in their α-granules. Platelet aggregation and activation, after vascular damage, results in the release of several GFs that may affect the chemotaxis, proliferation, and differentiation of mesenchymal stem cells (MSCs) or other committed cells during the process of tissue repair and healing. 

The GFs released from platelets include platelet-derived growth factors (PDGFs), changing growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF) and insulin-like growth factors (IGFs).

What Do The Studies Say About PRP?

To explore the possibility that platelet-rich plasma (PRP) could provide an autologous source of these essential GFs that benefit bone and soft tissue healing, many clinical and experimental studies dealing with the effects of PRP have been conducted. However, the benefit of PRP on bone formation is a controversial subject. While a report suggested a stimulatory impact with the addition of PRP, others have observed no improvement or have detected even inhibitory effects. 

Although the lack of standardization in application across these studies, including differences in the preparation method or dosage of PRP, biomaterials, species, implantation sites, and cell types, may have contributed to the inconsistent results, its hypothesized that the differences in GF composition among PRPs could lead to this discrepancy. 

How Does PRP Effect Growth Factors?

 Findings indicated that PRP induced proliferation in a dose-dependent manner. The addition of 10% PRP to the culture medium produced marked cell proliferation in vitro; this result was congruent with the findings of previous studies. Because higher concentration (30%) of PRP did not promote proliferation, as compared to controls, 10% PRP may be optimal for the experimental ex vivo expansion of mesenchymal stem cells (HMSCs).

Few studies have suggested the presence of negative regulators in PRP, such as thrombospondin, but the reason for the antiproliferative effect of high-concentration-PRP is not apparent. 

In a study, PRP suppressed the alkaline phosphatase (ALP) activity of mesenchymal stem cells (MSCs). Some studies have reported similar results in that PRP increased migration and proliferation, but reduced the osteogenic differentiation of bone marrow-derived MSCs in vitro. 

However, in this study, activated platelet-poor plasma (aPPP) did not suppress ALP activity at any concentration; therefore, these inhibitory effects may be associated with substances that are derived from platelets.

What Are The Results Of Pep Factor?

Pep Factor has consistent results among clients and has provided many people with youthful skin as well as renewed growth of hair. Researchers have made several innovations in molecular medicine and valuable ingredients for their delivery systems. Researchers are also researching more useful, cost-effective, and easy methods for skin and scalp cosmetics.

Our Pep Factor is created from the start with the purpose of magnifying Fibroblast. We want our kit to provide the maximum amount of benefits for what our clients need. FGF is responsible for the regeneration of tissue, including skin and hair follicles. UMA's research laboratory has designed this unique formula. FGF also directs a range of multiple biological functions, including cellular proliferation, durability migration. 

To grasp precisely how Platelet-rich plasma (PRP) works, you'll need to be aware of the role that platelets engage in healing. Platelets are a component of blood, including red and white blood cells. When a person gets a wound, the platelets are one of your body's first responses that come to a stop the bleeding and promote healing.

Researchers speculated that if they could obtain concentrated platelets and inject them into damaged areas of the body, they could accelerate healing. It's possible.

How Is It Made?

To produce PRP, a medical expert will draw a blood sample and place it into a device called a centrifuge. This device revolves at a fast rate, which separates the elements of the blood. The medical expert then extracts the platelets for injection.

Effects On Hair

Physicians have also used PRP to treat injuries to the muscles, tendons, and ligaments, and it's results are impressive, however, what does PRP do for hair loss? PRP holds a range of growth factors and proteins that promote tissue repair. Due to this, hair loss that results from damage to hair follicles could be helped by PRP to regrow hair.

Due to this reversal, PRP has become a popular method of restoring hair growth. PRP science is still out there, but the effects are apparent, it has impressive growth factors inside. 

Is PRP Effective For Hair Regrow?

There are loads of studies that back up the effectiveness of PRP for regrowing hair.

A team of researchers carried out a methodical examination of the research on PRP as a treatment for hair loss. Their conclusions appear in Aesthetic Plastic Surgery. The study focused on 11 research papers that involved a total of 262 participants who had androgenetic alopecia. Evidently, most of the studies found that doses of PRP reduced hair loss and enlarged the diameter of hairs and the area of hair growth.

In Dermatologic Surgery, they investigated the findings of 19 studies that focused on PRP as a treatment for hair loss. These studies recruited 460 people in total. According to the creators of the review, most studies proclaimed that PRP procedures led to hair regrowth.

Treatment seems to work for many people. However, it isn't the be-all-end-all for hair loss. Regardless, people who experience hair loss are willing to try what it takes to regrow their hair, so if it's possible for a majority, then people will try it. Some people will want an alternative.

Is there an alternative to PRP?

Yes. Our Pep Factor is created from the start with the purpose of magnifying Fibroblast. We want our kit to provide the maximum amount of benefits for what our clients need. FGF is responsible for the regeneration of tissue, including skin and hair follicles. UMA's research laboratory has designed this unique formula. FGF also directs a range of multiple biological functions, including cellular proliferation, durability migration. 

What Is The Procedure For PRP Hair Loss

PRP injections are as follows:

  1. A medical professional draws blood 
  2. the blood sample is placed in a centrifuge.
  3. A centrifuge spins the blood, segregating its components.
  4. The professional medical extracts the platelets 
  5. The expert then injects the platelets into areas of the scalp.

The whole process may take approximately 1 hour, and several sessions may be required. After receiving PRP treatment, a person can generally return to their regular activities without any limitations.

How Long Do The Effects of PRP Last?

PRP does not cure conditions that produce hair loss. Due to this, a person would need to receive recurring PRP treatments overtime to support hair growth results. Regardless, patients have to take medications frequently that doctors commonly use to treat androgenetic alopecia. PRP is an ever-evolving technology as well, so things may improve in time. 

Injection frequency depends on the patient and how well they are receiving PRP treatments. The doctor may suggest having maintenance injections every 3–6 months once hair loss is under control.

The Hamilton-Norwood scale (sometimes only referred to as "Norwood scale") is the primary classification system used in the medical field to gauge the degree of male pattern baldness. This measurement scale was first introduced by James Hamilton in the 1950s and later revised and updated by O'Tar Norwood in the 1970s.

Men tend to lose their hair in a few common patterns over the development of many decades. The Hamilton-Norwood scale provides quick reference images that show distinct stages of balding. This is important for doctors to classify the stage of balding.

There are many other classification scales used by doctors, researchers, and hair transplant surgeons. Different classification scales include male and female, or only female, but Hamilton-Norwood is typically used by practitioners when discussing male pattern baldness.

It presents a reference point to diagnose the degree of baldness, consider treatment options, and measure the effectiveness of any treatment.

The Seven Stages of Hamilton-Norwood

The Hamilton-Norwood scale has seven steps. Each step marks the severity and pattern of hair loss.

Stage 1. There is a lack of bilateral recessions along the anterior border of the hairline in the frontoparietal regions. No notable hair loss or recession of the hairline.

Stage 2. There is a small recession of the hairline around the temples. Hair is also lost, or sparse, along the midfrontal border of the scalp, but the depth of the affected area is much less than in the frontoparietal regions. This is commonly referred to as an adult or mature hairline.

Stage 3. The first signs of significant balding appear. There is a deep, symmetrical recession at the temples that are only sparsely covered by hair.

Stage 3 vertex. The hairline stays at stage 2, although there is notable hair loss on the crown of the scalp (the vertex).

Stage 4. The hairline recession is harsher than in stage 2, and there is scattered hair or no hair on the vertex. There are deep frontotemporal recessions, usually symmetrical, and are either bare or very sparsely covered by hair.

Stage 5. The areas of hair loss are more significant than in stage 4. They are still divided, but the band of hair between them is thinner and sparser.

Stage 6. The connection of hair that crosses the crown is gone with only sparse hair remaining. The frontotemporal and vertex regions are joined together, and the extent of hair loss is more significant.

Stage 7. The most drastic stage of hair loss, only a band of hair, going around the sides of the head persists. This hair usually is not thick and might be dainty.

Norwood class A. This is a somewhat different and less common classification of hair loss. Norwood also defined a Type A variant from his standard classification system, which is distinguished by two major features and two minor features.

Major features

1) the border of the hairline grows to the rear without leaving an island of hair in the mid-frontal region

2) there is no synchronous development of a bald area on the vertex. Rather, the frontal hairline recession keeps progressing to the rear of the scalp.

Minor features

1) there is sparse hair scattering in the area of hair loss  

2) the horseshoe-shaped areas of hair that continue on the side and back of the scalp tend to be more extensive and touch higher on the head.

How is male pattern baldness diagnosed?

Common male pattern baldness is usually diagnosed based on the form and pattern of hair loss, along with a comprehensive medical history, including questions about the predominance of hair loss in your family.

How is hair loss treated?

Hair loss treatments are most potent when started early. It's more manageable to slow down hair loss than it is to incite new hair growth. Hair follicles that stop creating hair become dormant after about two years and can't be reactivated. However, there are ways to rejuvenate your hair follicles and start-up hair growth, such as Laser Hair Growth Helmets, and Pep Factor.

Laser Hair Growth Helmets. Low-level laser therapy is known as red light therapy and cold laser therapy, highlights, and empowers photons in the scalp tissues. These photons get absorbed by weak cells, which then encourages hair growth. At FACE, we use this type of treatment in our Laser Hair Growth Helmets.

Pep Factor. This serum is designed from the first drop with the intention of magnifying Fibroblast. Fibroblast Growth Factors (FGF) directs a range of various biological functions, including cellular proliferation, durability migration. FGF is also responsible for the renewal of tissue, including skin and hair follicles. UMA's research laboratory has designed this unique formula. 

Telogen effluvium (TE) is probably the second most prevalent form of hair loss. It is a crudely defined condition due to there being little research to understand TE. Essentially TE occurs when there is a shift in the number of hair follicles producing hair. In the event that the number of hair follicles producing hair decreases drastically for any purpose during the resting(telogen phase), there will be a notable increase in dormant (telogen stage) hair follicles. 

What Does Telogen Effluvium Look Like?

TE appears as a scattering of thin head hair, which may not be even all over. It can be more severe in specific areas of the scalp than others. The hair on top of the scalp tends to thin more than it does at the sides and back of the scalp. There is usually no hairline recession, save a few rare severe cases. The shed hairs tend to be telogen hairs, which can be identified by a tiny bulb of keratin on the root. 

How Can Telogen Effluvium Develop?

There are two essential forms TE can develop, and that can show up through various means and or events, which we will go over later. 

Shock. An environmental abuse that "shocks" the growing hair follicles so to the point that they go into a resting state. This results in a rise in hair shedding and thinning of hair on the scalp. This form of TE can develop rapidly and may be noticeable one or two months after receiving the shock. 

Persistent Stressors. The second form of TE occurs more gradually and continues longer. The hair follicles may not all abruptly shed their hair fibers and enter a resting telogen state. In this form of TE, there may not be much noticeable hair shedding, but there will be a gradual thinning of the scalp hair. Persistent stresses can produce this form of Telogen Effluvium.

These forms can show up through various methods such as:

Is Telogen Effluvium Treatable?

The science is still out when it comes to Telogen Effluvium. In short, there are ways to reverse, slow down, and repair your hair if you're living with this condition. Mending any of the above "states" can support your body, and there are some products we supply that can speed up and have your hair better than ever.

Pep Factor is a serum designed from the first drop with the intention of magnifying Fibroblast. Fibroblast Growth Factors (FGF) directs a range of various biological functions, including cellular proliferation, durability migration. FGF is also responsible for the renewal of tissue, including skin and hair follicles. UMA's research laboratory has designed this unique formula. 

Androgenetic alopecia (male or female patterned baldness) is a prevalent form of hair loss in both men and women. Hair is lost in a clear pattern, starting above both temples. As time passes, the hairline shrinks to form an infamous "M" shape. Hair also thins at the top, often advancing to partial or total baldness.

The pattern of hair loss found in women is different from male-pattern baldness. For women, the hair becomes thinner all over the head, and the hairline does not shrink. Androgenetic alopecia in women seldom leads to total baldness.

How Common Is Androgenetic Alopecia?

Androgenetic alopecia is a widespread cause of hair loss in both men and women. This kind of hair loss afflicts approximately 50 million men and 30 million women in the United States. Androgenetic alopecia can start as quick as a person's teens and the risk rises with age; more than 50 percent of men beyond the age of 50 have some stage of hair loss. In women, hair loss is most apparent after menopause.

What Causes Androgenetic Alopecia?

A variety of hereditary and environmental circumstances represent a part in inducing androgenetic alopecia. Although researchers are examining risk factors that may add to this condition, most of these factors remain hidden. Researchers have discovered that this kind of hair loss is linked to hormones called androgens, especially an androgen called dihydrotestosterone. Androgens are essential for normal male sexual maturation before birth and during puberty. Androgens also have other vital roles in both males and females, such as managing hair growth and sex drive.

Hair growth starts beneath the skin in structures called follicles. Each strand of hair grows typically for 2 to 6 years, goes into a resting phase for some months, and then falls out. The sequence starts over when the follicle begins growing a new hair. A spike in the levels of androgens in hair follicles can cause a shorter cycle of hair growth and produce shorter, more delicate strands of hair. Unfortunately, this also creates a delay in the growth of new hair to replace strands that are shed.

Two Ways Reverse Androgenetic Alopecia

Laser Hair Growth Helmets. Low-level laser therapy is known as red light therapy and cold laser therapy, highlights, and empowers photons in the scalp tissues. These photons get absorbed by weak cells, which then encourages hair growth. At FACE, we use this type of treatment in our Laser Hair Growth Helmets.

Laser helmets are indispensable in treating hair loss, but not all lasers are produced equal. FACE's product has 272 diode lasers that are developed especially for high-efficiency lasers that allow releasing the most significant volume of light and coverage for the total scalp area. The lasers are precisely crafted to encourage supreme hair growth. Laser Helmet lasers are known to reverse the thinning of follicles. Follicles will then ultimately return to their healthy natural state after being exposed to our specific lasers. 

Pep Factor. This serum is designed from the first drop with the intention of magnifying Fibroblast. Fibroblast Growth Factors (FGF) directs a range of various biological functions, including cellular proliferation, durability migration. FGF is also responsible for the renewal of tissue, including skin and hair follicles. UMA's research laboratory has designed this unique formula. 

FGF(Fibroblast Growth Factors) incites hair growth and are involved in the management of hair morphogenesis and the hair growth cycle. A recent study investigated the hair growth-promoting liveliness of three approved growth factor drugs, fibroblast growth factor 10 (FGF-10), acidic fibroblast growth factor (FGF-1), and basic fibroblast growth factor (FGF-2), and the method of how they all acted. 

A Rise In Hair Loss

Hair is deemed an accessory structure of the integument along with oil glands, sweat glands, and nails. Hair follicle formation needs the intricately managed regulation of apoptosis, proliferation, and differentiation. Hair follicles are mini-organs that, during postnatal life, cycle through periods of anagen (growth phase), catagen (regression phase), and telogen (resting phase)

Hair loss is regularly not a life-threatening event; however, it can severely impact one's life. The number of patients suffering from hair loss has risen in the past few years. Some of these individuals deal with a hit to their self-esteem, confidence, and vitality.  

Does FGF Stimulate Hair Growth?

Fibroblast growth factors have potential application in hair growth. The study that this article is based on tested their results on rats. 

To assess the hair growth potential of FGFs, they topically applied FGF-1, FGF-2, and FGF-10 on shaved mice. Each week they would determine the amount of hair growth based on the color of the skin.

At two weeks, three FGFs produced black coloration in the shaved skin of the mice. FGF-10 group expressed the most black coloration, while very less visible hair growth and black coloration were observed in the control group. 

At three weeks, the FGFs group showed increased hair growth, and FGF-10 stimulated hair growth over 50% of the shaved area. 

At four weeks, they observed that hair growth from FGF-1 and FGF-2 was only happening in select areas. However, the control group showed less hair growth. 

To confirm that FGFs promoted hair growth, they measured the length of 10 hairs plucked from each mouse at 2, 3, and 4 weeks. The length and strength of hairs in FGF-10, FGF-1, and FGF-2 treated group was remarkably longer than that of the control group, and FGF-10 had the most vigorous activity of hair growth. 

Pepfactor is created from the start with the purpose of magnifying Fibroblast. FGF directs a range of multiple biological functions, including cellular proliferation, durability migration. FGF is also responsible for the regeneration of tissue, including skin and hair follicles. Facemed's Pep factor utilizes every facet of FGF to ensure optimal results. 

Results

FGF increased the number and the size of hair follicles during anagen phase induction. An improvement in the number of hair follicles is an indicator for the transition of hair growth from the telogen to anagen phases. The hair in FGF-10, FGF-1, and FGF-2 treated group appeared much more soon than those in the control group. While the number of hair follicles of the relative area in FGFs managed group was greater than in the control group, topical application of FGF-10 showed the maximum amount of hair follicles as compared to FGF-1 and FGF-2 groups.

You're losing hair regardless of how healthy your hair is. In fact, its around 50-100 hair follicles a day! That might seem significant, but it won't be noticeable unless your hair regrowth slows down. That's where we at FACE come in as experts of hair growth. We have used low-level laser therapy to maintain and rejuvenate hair growth.

Our Helmets are equipped with 678nm diodes which creates the optimal results to stimulate hair growth. This will, improve hair oil quality, support hair regrowth, and build up existing hair follicles. This makes our helmets some of the most up to date technology on the market, give you the best results possible.

What Can Cause Hair Loss?

Of the 100 hairs, we lose from our scalp, the majority of people grow those hairs grow back, some people don't due to multiple factors that happen genetically or by life circumstances. These hair loss factors include: 

Regrowing hair after any of those factors can be difficult, but at FACE, we manage to do it regardless of the circumstances. How do we do it? 

Lasers. Sounds pretty awesome, and it is. By using our helmets, you can see significant results when it comes to your hair. There are many benefits to using our helmet, such as:

What is Low-level laser therapy?

Low-level laser therapy, also known as red light therapy and cold laser therapy, highlights and empowers photons in the scalp tissues. These photons get absorbed by weak cells, which then encourages hair growth. At FACE, we use this type of treatment in our Laser Hair Growth Helmets.

Laser treatment works for hair loss by using low-dose laser treatments that stimulate blood flow to hair follicles. By using this method it stimulates and encourages hair follicles to grow hair. This study in 2014 shows that it is a safe and effective method of hair regrowth. 

What are Laser Helmets?

Laser helmets are vital in treating hair loss, but all lasers are not created equal. Our product has 272 diode lasers that are specially developed, high-efficiency lasers that allow delivering the most significant amount of light and coverage for the total scalp area. The lasers are precisely crafted to promote maximum hair growth. Laser Helmet lasers reverse the thinning of follicles. Follicles will then eventually return to their normal healthy state after being exposed to our specialized lasers.

Over time your hair will start to thin and eventually stop growing. Reversing hair thinning is the first step to getting your hair back by halting any further loss after the first 20 or so treatments. The next stage is re-growing your hair. Laser Helmet also grows hair after around 52 treatments.

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