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Fibroblast growth factor (FGF)2/basic FGF is a member of the fibroblast growth factor family. Its role in skin tissue healing is well known in the medical community. Still, the function of other FGFs in skin tissues remains unclear. In this recent study, they studied FGF composition patterns in the heart, liver, skin, and kidney tissues. Compared to other tissues, only four FGFs were dominant in the skin.

To discover FGF function in the tissue healing cycle, mice fibroblast cells were treated with FGF2, FGF10, and FGF21, and cell migration was closely watched. The results showed that FGF treatment improved cell migration, which is an essential step in wound healing. Also, FGF therapy improved the activity of c-Jun N-terminal kinase (JNK), which is a crucial regulator of fibroblast cell movement. 

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How Does It Heal Wounds?

Human genomes contain 23 members of the fibroblast growth factor family, which are necessary for metabolism and growth. FGF21 is the most researched family member and has been most commonly found in the liver early in development. Skin tissue repair needs the assistance of different cell types, including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. 

Fibroblast cell generation and migration, collagen deposition, and remodeling wound contraction, and angiogenesis are essential steps of tissue repair. Extracellular matrix forms the most significant component of the dermal skin layer; therefore, the repair of ECM is critical to wound healing. Fibroblasts form an essential cell layer that aids in the production and restoration of the ECM, and their proliferation and migration is vital for the formation of granulation tissue and skin repair. 

Is FGF Effective at Healing the Skin?

GF2/bFGF is a member of the FGF family, and its effectiveness in the growth of fibroblast cell migration is recognized in the medical community. In the study, it was observed that FGF2, FGF7, 10, and 21 are highly expressed in skin tissue. Previously, the role of FGF21 in glucose homeostasis has been well known, and its generation is started by stress in the liver and heart. However, in the study, FGF21 appearance was shown to be most significant in the skin, where expression was even higher than in the liver.

Even more impressive is that FGF21 was shown to accelerate the migration of mouse fibroblast cells, similar to FGF2. Also, FGF10 was identified as predominant in the skin and even accelerated cell migration. FGF2 has been known to expedite fibroblast cell migration via activation of the phosphoinositide 3-kinase-Ras-related C3 botulinum toxin substrate 1-JNK signaling pathway. Something else discovered in the study was that FGF2, 10, and 21 treatment increased JNK phosphorylation levels. FGF7 has the highest expression of all FGFs in the skin; however, overexpression of FGF7 in fibroblast cells did not alter cell migration speed, implying that FGF7 may have alternative roles in skin tissue.

Numerous FGFs were comparatively highly expressed in the heart, liver, and kidney, implying the potential roles of these FGFs in different tissues. Notably, FGF1 was one of the dominant FGFs in all the tissues tested besides the skin. The findings of the study show that FGF family members FGF2, 10, and 21 coordinate to stimulate the FGF signaling pathway, which is essential in the development of wound repair. 

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Platelet-rich plasma (PRP) is created by combining platelets found in whole blood. It can aid in tissue regeneration, bone regeneration, and wound repair.

Platelet-rich plasma treatment has also been suggested to promote hair growth, encourage cell survival and reproduction, and lengthen the anagen phase of the hair cycle.

During the treatment, a technician draws your blood and spins it in a centrifuge to separate the platelets and plasma. Doctors then inject the plasma, which helps repair blood vessels, promote cell growth and wound healing, and stimulate collagen production.


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PRP kits

Selphyl. This product allows for the prolonged release of platelet growth factors in the scalp to help hair grow. This extended-release stimulates stem cells, prolongs dermal papillae cell survival, and increases angiogenesis. These factors combine to lengthen the anlagen phase of hair growth and shorten the catagen (resting) phase. The result is increased hair diameter and hair follicle durability.

ReGen. The product’s main ingredient, Minoxidil, was developed in the 1950s to treat conditions, such as ulcers and high blood pressure. Researchers discovered that the product could revive hair follicles and reverse both male and female pattern baldness (androgenic alopecia). The ingredient is essentially a potassium channel opener capable of causing the hyperpolarization of cell membranes.

Eclipse. Tends to offer fewer steps than other PRP kits available. It is an established system that is based on blood separation according to mass using a unique division gel. The system allows for the preparation of complete Platelet-Rich Plasma (PRP) with optimal platelet groups and cellular content.

Magellan. It cost much more than the other systems, but the results will typically be more prominent. The method begins by drawing blood, 60-120cc. The blood is then put in the Magellan processor to insulate the PRP, which takes about 15 minutes per 60cc of blood. During this time, the scalp is dulled up with both topical creams as well as shots. When numb, the scalp is injected with a vitamin mixture as well as with the solution. Afterward, the PRP injection is then performed. 

FGF Kits

Pepfactor is created from the start with the purpose of magnifying Fibroblast. FGF directs a range of multiple biological functions, including cellular proliferation, durability migration. FGF is also responsible for the regeneration of tissue, including skin and hair follicles. UMA’s research laboratory has designed this unique formula. 

How Does FGF Compare?

Scientists identified the Fibroblast Growth Factor (FGF) in pituitary extracts in 1973. FGFs are cell proteins that exert their physiological functions through coordinating developmental pathways, managing events in the early embryo through the growth of multiple organ systems. A defining feature of FGFs is that they adhere to heparin and heparan sulfate. 

In this research study, scientists compiled an abundance of data to establish the strengths of FGF for the use of hair regrowth. Here are some of the results seen in the study.

The data and examination of FGF on hair growth are reliable, and I encourage you to read the full report to see how comprehensive the research was. I believe this evidence shows that FGF is an excellent alternative to using PRP for hair growth.