PDRN and PN are injectable skin boosters from salmon DNA that rejuvenate aging skin. To recommend the best skin booster for each patient, assess their needs and determine if concentrated PN or gentle PDRN better targets their concerns.
Injectable skin boosters like PDRN and PN have become incredibly popular for their ability to rejuvenate aging skin. But with two very similar options available, how do you know which one is right for patients’ needs?
In this comprehensive guide, we’ll break down the key differences between PDRN and PN so you can determine which facial injectable is best suited for each skin concern and goals.
What are PDRN and PN Skin Boosters?
PDRN stands for Polydeoxyribonucleotide, which is a type of polynucleotide sourced from salmon sperm DNA. It contains a high concentration of DNA fragments that provide building blocks to stimulate cell metabolism and tissue repair. PDRN skin boosters also typically contain additional beneficial ingredients like hyaluronic acid for enhanced hydration and anti-inflammatory effects.
PN stands for Polynucleotide. It also contains DNA sourced from salmon, but at a higher concentration than most PDRN solutions. PN products are focused on delivering a robust amount of polynucleotides, without supplementary ingredients.
While both can provide rejuvenating effects, the concentration levels and inclusion of other components impact the treatments’ procedures and results.
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Key Differences Between PDRN and PN
There are three main differences to note between PDRN and PN injectable skin boosters:
- Concentration Levels
PDRN features a lower concentration of polynucleotides compared to PN. Most PDRN solutions contain approximately 3-5mg/mL of DNA fragments, while PN boosters contain around 10-14mg/mL.
The higher levels in PN products are thought to elicit more pronounced effects, especially for severe signs of aging. However, lower concentrations in PDRN may benefit those with milder skin concerns or very sensitive skin.
- Additional Ingredients
In addition to the polynucleotides, PDRN solutions also incorporate ingredients like hyaluronic acid and various vitamins. The added components boost hydration and target specific skin concerns.
PN treatments only contain the concentrated polynucleotide formula without supplementary ingredients. This allows the DNA fragments to work directly at stimulating tissue regeneration.
- Treatment Approach
Given the differences in composition, PDRN and PN are sometimes used at varying strengths and intervals. Although protocols can vary, PN is often administered less frequently than PDRN due to the highly concentrated formula.
For optimal results, you can tailor the treatment plan and product selection based on the patient’s individual skin needs and goals.
What are the Key Benefits of PN vs PDRN?
PDRN and PN share a range of overall benefits for rejuvenating facial skin, including:
- Increased hydration and elasticity
- Plumping of fine lines and wrinkles
- Brighter, more even complexion
- Smoother skin texture
- Stimulated collagen production
- Enhanced skin repair and regeneration
These general perks make injectable skin boosters a popular anti-aging treatment for the face, neck, décolleté and hands. The dramatic yet non-invasive improvements contribute to a more youthful appearance.
PN-Specific Benefits
The ultra-concentrated PN formula provides additional advantages, including:
- More pronounced, longer-lasting results for severely aged skin
- Potentially more effective rejuvenation in certain areas like the delicate under eye region
- Ability to incorporate higher concentrations tailored to advanced skin concerns like deep wrinkles
PN’s robust polynucleotide content makes it ideal for those seeking intensive anti-aging effects. Concentrations can be adjusted based on the severity of damage and desired outcome.
PDRN-Specific Benefits
While less concentrated, PDRN solutions offer advantages like:
- May be suitable for a wider range of mild to moderate skin concerns
- Additional skin-nourishing ingredients like hyaluronic acid target hydration and inflammation
- Lower polynucleotide levels may benefit sensitive skin
For some individuals, PDRN’s lower concentration and built-in hydrating and soothing agents are a better match. It promotes skin renewal while supporting overall skin health.
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Who are the Best Candidates for Each Treatment?
When determining which facial injectable is right for each patient, consider the following factors:
In general, the optimal candidates for PDRN and PN skin boosters include:
- Individuals seeking to address common aging concerns like fine lines, wrinkles, dullness, and uneven skin tone
- Those looking to improve visible signs of skin damage due to environmental stressors
- People wanting to enhance facial skin hydration, elasticity and collagen density
Specific factors to consider:
| PN Candidates | PDRN Candidates |
| Individuals with moderate to severe facial wrinkles and skin laxity. | Those with mild to early moderate signs of facial aging. |
| Those seeking intensive, longer-lasting rejuvenation, especially for high-movement areas. | People who want a skin-boosting treatment with minimal downtime. |
| People wanting to target extremely damaged or fragile skin, such as thin under eye skin. | Individuals with sensitive skin prone to redness or irritation. |
| Anyone seeking to supplement other anti-aging therapies and improve overall skin health. |
The level of skin concerns and desired results help determine whether PDRN or PN is the better choice.
How Do PDRN and PN Treatments Compare in Price and Duration?
The costs and duration for PDRN and PN treatments can vary based on several factors:
Pricing Factors
- Concentration of polynucleotides
- Volume or amount of solution used per session
- Number of treatment sessions recommended
- Geographic location and clinic/practitioner qualifications
In general, PN costs more per session than PDRN. But pricing ultimately depends on the specifics of your customized treatment plan.
Duration Factors
- Both PDRN and PN involve an initial round of treatments (usually 4-6 sessions)
- Maintenance sessions are often advised every 6-12 months
- Appointment frequency may differ based on which booster you receive
You can help determine the ideal treatment and maintenance schedule of your patients based on their preferred product and personal objectives.
What are the Potential Side Effects of PN vs PDRN?
When administered properly by an experienced professional, PDRN and PN treatments come with minimal risks. Potential side effects include:
Common Short-Term Effects
- Mild swelling, redness and tenderness around injection sites
- Minor pinpoint bruising at injection points
These resolve quickly, within a few days following treatment.
Rare Risks
- Allergic reaction, though formulas are generally non-allergenic
- Overly concentrated formulas may cause moderate irritation in some individuals
The Takeaway
While PDRN and PN take different approaches, both can produce restorative results for aging skin. Keep these key points in mind when deciding which is best for your patients’ needs:
- PN features higher polynucleotide concentrations for intensive anti-aging effects.
- PDRN offers moderate polynucleotide levels plus hydrating and soothing ingredients to target various concerns.
- PN may be optimal for severe wrinkles and skin laxity.
- PDRN may suit a wider range of individuals including those with sensitive skin.
- Treatment plans, including optimal product choice and strength, duration, and price, can be customized for unique goals.
There is no universally superior option. The most important step is consulting an experienced cosmetic professional for their expert product recommendation and treatment plan. An injector skilled in both PDRN and PN can help achieve the patient’s desired aesthetic outcome safely and effectively.
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