How Painful is PRP Injection for Hair Loss?

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Platelet-rich plasma injection is one of the safer procedures that doesn’t require going under the knife unlike the more traditional hair transplant procedures. However, it’s still a daunting procedure, especially for those that are afraid of injections. This draws a dilemma for patients with androgenetic alopecia who are really willing to undergo the procedure but are having second thoughts because of how painful the procedure might be.

So how painful is PRP injection for hair loss? Platelet-rich plasma injections are made as comfortable and as painless as possible by the professionals who perform the procedure. They apply anesthesia before the scalp injections, they use very fine needles for the procedure, and they also provide ice packs to the patient after the procedure. Some may also opt to use a vibration device which is also proven to numb pain during injections.

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How the PRP Injection Procedure Goes

Platelet-rich plasma is a formulation taken from the own blood components of the patient. It’s done first by doing a blood draw in the blood vessel of the patient. This blood sample will then be centrifuged to separate the other blood components from plasma and concentrate the platelets in plasma.

The injection process is then done by intradermal injections of platelet-rich plasma in the hair, evenly spaced so that all the parts experiencing hair loss will be covered.

Some clinical studies have shown that platelet-rich plasma injections are an effective treatment modality against hair loss with good effectiveness, safety, and patient satisfaction profiles. Although some also don’t, and this may be due to the difference in the methods of preparation of PRP, which still aren’t standardized as of writing.

It works through the release of growth factors by the high concentration of platelets present in the formulation and acts as a tissue regeneration treatment for hair loss.

These growth factors act by increasing the blood flow in the area and support the growth of hair follicles by providing adequate oxygenation and nutrition. They also act by prolonging the anagen (growth) phase of the hair cycle, leading to prolonged and visible hair growth.

Ways How Clinics Make PRP Injections Comfortable

Clinics where platelet-rich plasma injections are offered make sure that the patients would feel only minimal to no pain during the procedure. These clinics aim to make the procedure as comfortable as possible, employing the following techniques to lessen the pain during the procedure:

  • Using anesthesia before the scalp injections – Anesthesia injections are numbing agents that help make the area numb so you won’t feel anything during the whole duration of platelet-rich plasma therapy for hair loss. It may be done by injecting a dose of anesthesia on the scalp or applying a numbing cream to the area where the PRP injections will be done.
  • Using vibration anesthesia devices – Vibration devices are slowly becoming a popular method among clinics because of their proven effectiveness in reducing pain during injections. This technique works by providing a sort of massage to the area where it’s applied and also helps in fluid dissolution in this area.
  • Using very fine needles for the procedure – The size of needles used in the injections of platelet-rich plasma varies per clinic, although typical sizes they use include 25, 27, 30, or 31 gauge. Note that the higher the number of needle sizes, the smaller the needle will be.
  • Giving ice packs after the procedure – Ice packs help in numbing the area where the injection is administered. It also helps reduce inflammation and bleeding in the area where it’s applied. 

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Safety of PRP Injections for Hair Loss

Platelet-rich plasma injections are generally safe and minimize the risk of contracting allergic reactions and communicable diseases because it’s taken from the blood cells of the patient. It also requires no downtime and no long healing process because it’s a minimally invasive and outpatient procedure.

Side effects are typically mild, which include pain, redness, and swelling, which are all associated with the injection procedure and not with the formulation itself. Rarely, tissue and nerve injuries may occur, although it’s more associated with the skills of the professional doing the procedure.

PRP injections also aren’t for everyone, though. People with autoimmune diseases such as systemic lupus erythematosus and other medical conditions like low platelet counts and active infections must also not undergo this procedure.

With the guidance of your healthcare provider, blood thinners must also be avoided prior to the procedure because these medications may reduce the effectiveness of the platelet-rich plasma therapy. This is because they adversely affect platelet activation, which is vital in the release of growth factors which are the reasons behind why PRP injections work.

PEP Factor: A Pain-Free, High-Quality Formulation For Hair Loss 


Platelet-rich plasma injections are made as comfortable as possible by the medical professionals doing the procedure.

However, if you’re still unconvinced and think that you can’t endure the scalp pain that goes with the procedure but also would like to find an effective medical treatment to improve your hair thickness, then you should try FACE Med Store’s PEP Factor.

PEP Factor is a pain-free, high-quality formulation because it’s applied topically on the scalp. Because of its mode of application, it’s mostly risk-free and can be safely applied without major side effects associated with other cosmetic procedures for hair regrowth.

Also because of its topical application, it can be safely combined with other procedures like microneedling for the improvement of hair thinning and for more optimum results.

PEP Factor helps improve the appearance of hair in a variety of types of hair loss like pattern baldness. This is through its natural, nourishing ingredients, most notably the basic fibroblast growth factor (bFGF) and copper peptide.

The bFGF has cell growth properties that can help promote the growth of cells in the hair follicles, much like the concentration of growth factors found in platelet-rich plasma.

On the other hand, the copper peptide has antioxidant properties which can help avoid the worsening of oxidative stress-related hair loss by neutralizing the damaging free radicals produced by the processing of oxygen.

PEP Factor may also be used in the skin, where it helps brighten the skin and provide skin rejuvenation also by applying it topically to the skin.

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Platelet-rich plasma therapy sessions are made as comfortable as possible using different techniques that can reduce the pain that may be involved in the procedure. These techniques include providing anesthesia, using small needles, and giving ice packs after the procedure.

At FACE Med Store, we strive to make sure that you won’t experience the stress of looking for your hair care needs. We provide high-quality supplies and formulations complemented with our friendly customer service for all your beauty and medical needs. Contact us today at to know more about our products.

All content in this blog is for informational purposes only. It is not medical or legal advice. Please consult with lawyer or a medical professional.